Arena JE, Brown RD, Mandrekar J, Rabinstein AA. 10.1016/j.neurol.2014.11.Subjects with transient epileptic amnesia attacks may go unrecognized. Transient epileptic amnesia is an emerging concept described in middle-aged and older people with an evident response to antiepileptic drug treatment (AED). TGA usually occurs as a single attack and does not recur. Syndromes of transient amnesia: towards a classification. In patients with epilepsy, memory dysfunction is not an unusual complaint. It usually lasts 1-8 hours and recovers without need for treatment. High-field, T2 reversed MRI of the hippocampus in transient global amnesia. Most patients experience other seizure types compatible with an origin in the temporal lobes, but transient amnesia is the only manifestation of epilepsy in. Nakada T, Kwee IL, Fujii Y, Knight RT.Both represent potentially reversible memory disturbances and have a treatment based on antiepileptic drugs. Transient global amnesia: clinical characteristics and prognosis. Two atypical clinical epileptic syndromes should be pointed out in the elderly: the transient epileptic amnesia and the epileptic pseudodementia. Miller JW, Petersen RC, Metter EJ, Millikan CH, Yanagihara T.Acute-Onset Amnesia: Transient Global Amnesia and Other Causes. What Does Transient Global Amnesia Really Mean? Review of the Literature and Thorough Study of 142 Cases. Quinette P, Guillery-Girard B, Dayan J et al. The aetiology of TGA has been under discussion for years, advocating ischaemic, migrainous, epileptic and other causes. 8 We would suggest an epileptic aetiology for the attack reported by McCorry and Crowley, 1 rather than TGA. doi:10.1161/STROKEAHA.107.508655 - Pubmed However, pure prolonged transient amnesia can occur in the form of non-convulsive status epilepticus. Transient Global Amnesia: Diffusion-Weighted Imaging Lesions and Cerebrovascular Disease. Optimal Diffusion-Weighted Imaging Protocol for Lesion Detection in Transient Global Amnesia. High-Resolution Diffusion-Weighted Imaging Increases Lesion Detectability in Patients with Transient Global Amnesia. TEA responds well to low doses of medicine used to treat epilepsy, (such as carbamazepine, lamotrigine or sodium valproate) resulting in a cessation of seizure. Expect your symptoms to go away with time. doi:10.1016/S0140-6736(11)61304-4 - Pubmed How can you care for yourself at home There is no treatment for TGA. Post-traumatic amnesia, has a history of trauma 6 Psychogenic amnesia, more-so affects semantic memory compared to episodic memory, while TGA is the opposite 6ĭrug-related amnesia, typically has features of encephalopathy 6 Transient epileptic amnesia, typically presents upon waking while TGA does not 6 hippocampal ischemic), typically exists with other neurological deficits 6 The condition rarely recurs in ~5% of patients 5,6. These changes generally appear after symptom resolution, and the highest rate of detection is approximately 2 days after symptom onset 6. Accelerated long-term forgetting and autobiographical amnesia, which are invisible to standard memory tests, help to explain the discrepancy between normal test performance and prominent memory complaints among patients with epilepsy. These lesions can be bilateral and even multifocal 2-4. Summary: Transient epileptic amnesia is an under-recognized but treatable cause of transient memory impairment.
Prospective and retrospective studies based on a small number of transient global amnesia patients can detect small punctate regions of abnormally restricted diffusion on DWI/ADC sequences in the CA1 area of the hippocampus (lateral edge of the hippocampal gyrus abutting the temporal horn). Objective: Transient epileptic amnesia (TEA) is a form of adult-onset epilepsy where presenting features are well described, but little is known regarding prognosis.
Radiographic featuresĬT brain and conventional sequences of MRI brain may show no abnormalities, especially while the patient is symptomatic. epileptic phenomena, stroke, focal ischemia) have been proposed with no consensus on the exact mechanism 1,6. In conclusion, the differential diagnosis of transient amnesia may be challenging. Most cases show complete resolution of symptoms within a few hours from onset of symptoms 6. Episodic memories are more-so affected than semantic memories 6. The main symptom of transient global amnesia is being unable to create new memories and remember the recent past. AssociationsĪnterograde and partial retrograde amnesia lasting less than 24 hours without any other neurological or congestive symptoms 6. Transient global amnesia is most common in the 50-70 year age range ref.
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